Document 1067
 DOCN  M9471067
 TI    Increased survival and development of lymphoma in murine
       immunodeficiency disease (MAIDS): effects of lithium and magnesium in
       vivo (Meeting abstract).
 DT    9409
 AU    Gallicchio VS; Cibull ML; Hughes NK; Tse KF; Univ. of Kentucky and
       Veterans Administration Medical Centers,; Lexington, KY 40536
 SO    FASEB J; 7(4):A692 1993. Unique Identifier : AIDSLINE ICDB/94696889
 AB    Murine immunodeficiency disease (MAIDS) induced with LP-BM5 strain of
       MuLV is a disease that shows many similarities to human HIV-infection.
       Lithium (Li) influences many aspects of immunohematopoietic cellular
       proliferation and differentiation and is an antagonist to magnesium (Mg)
       dependent reactions. We describe here results of in vivo studies
       investigating the effects of Li and Mg (1 mmol placed in the drinking
       water) treatment in MAIDS-infected mice. Viral control, Li and Mg
       treated C57BL/6 mice were monitored for survival and MAIDS pathology.
       Virus-treated mice were grouped to receive Li po as follows: (1) 48 hr
       before virus; (2) at the same time as virus and (3) 5-wk postvirus. Mg
       was given 5-wk postvirus. After 22 wk of observation, percent survival
       was as follows: virus controls, 20%; Mg, 5 wk postvirus, 40%; Li, 5 wk
       postvirus, 80%; Li, at the time of virus, 85%; and Li, 48 hr prior to
       virus, 100% survival. Lymphoma, measured by splenomegaly (gms) was
       significantly reduced: normal age-matched controls 0.1 +/- 0.01; virus
       controls, 0.83 +/- 0.2, Mg, 5 wk postvirus, 1.47 +/- 0.12; Li, 5 wk
       postvirus, 0.47 +/- 0.02; and Li, at the time of virus, 0.28 +/- 0.1 (p
       value less than 0.01). These data suggest cations such as Mg and Li may
       play an important role in MAIDS pathogenesis and also indicates Li may
       be an efficacious agent in altering the pathogenesis and lymphoma
       characteristic of this retroviral disease in mice.
 DE    Animal  Cell Division/*DRUG EFFECTS  Lithium/PHARMACOLOGY/*THERAPEUTIC
       USE  Lymphoma/COMPLICATIONS/*DRUG THERAPY
       Magnesium/PHARMACOLOGY/*THERAPEUTIC USE  Mice  Mice, Inbred C57BL
       Murine Acquired Immunodeficiency Syndrome/COMPLICATIONS/*DRUG
       THERAPY/PATHOLOGY  MEETING ABSTRACT

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).